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Unique CoQ10 Delivery System Utilizing Patented VESIsorb ® Nano-Colloid TechnologyDougatories ®DESCRIPTION Citrus Solu-Q ™, provided by Douglas Laboratories®, is a Caplique™ containing natural coenzyme Q10 in a patented, naturally self-assembling nano-colloid system for enhanced absorption.FUNCTIONS Coenzyme Q10 is a fat soluble nutrient that is poorly soluble in water and is not well absorbed well taken orally. Coenzyme Q10 is an important rate-limiting nutrient that is a cofactor in the mitochondrial electron transport chain, the biochemical pathway in cellular respiration from which adenosine triphosphate (ATP) and metabolic energy is derived. Since nearly all cellular activities are dependent upon energy, coenzyme Q10 is essential for the health of all human tissues and organs. Given the strength of the science that has been emerging for the use of supplemental CoQ10, it is important to ensure that optimal CoQ10 levels are achieved in the blood following supplementation. Citrus Solu-Q ™ is unique among coenzyme Q10 products as it utilizes the patented VESIsorb® technology to deliver coenzyme Q10 without the need for concomitant fat consumption. When mixed with an aqueous system, this patented technology results in the formation of a nano-colloid containing solubilized CoQ10. This association colloid delivery system contains a highly uniform distribution of droplets that are less than 100 nm in diameter. The size and structure of these droplets allow for enhanced solubility and absorption of coenzyme Q10 (figure 1). This image represents the structure of a nano-colloid droplet which consists of a monolayer with the coenzyme Q10 contained within core. The formation other colloidal system upon contact with an aqueous environ(such as the lumen of the intestine) enables the solubilized CoQ to more eaunstirred water layer that is present between the enterocyte and the lumen of the intestine (figure 2). One can demonstrate the enhanced solubility of the CoQ10 contained in Citrus Solu-Q™ by placing a capsule in warm water. Once the capsule opens, the contents can be easily mixed with the water, resulting in the formation of the association colloid. There is no separation of oil and water phases as is typical with more traditional CoQ10 delivery systems.In a clinical study in humans, supplementation with CoQ10 utilizing the patented VESIsorb ® technology resulted in greater absorption compared with other CoQ10 products (figure 3).Figure 1 Figure 2
Figure 3
(continued on next page) INDICATIONS Citrus Solu-Q ™ may be a useful dietary adjunct for individuals wishing to supplement their diets with a highly absorbable form of CoQ10.FORMULA (#200054)SUGGESTED USE Adults take 1 Caplique ™ daily or as directed by your healthcare professional.SIDE EFFECTS None reported HOW SUPPLIED Boxes of 30 or 60 Capliques ™STORAGE Store in a cool, dry place, away from direct light. Keep out of reach of children. REFERENCES Cooke M, Et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008 Mar 4; 5:8. Folkers K, Simonsen R. Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochim Biophys Acta 1995;1271:281-6. Nicolson GL, Conklin KA. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastic disease by molecular replacement therapy. Clin Exp Metastasis. 2008; 25 (2): 161-9. Epub 2007 Dec 5. Tiano L, Belardinelli R, Carnevali P, Principi F, Seddaiu G, Littarru GP. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Eur Heart J. 2007 Sep; 28 (18): 2249-55. Epub 2007 Jul 19. Tran UC, Clarke CF. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion. 2007 Jun; & Suppl: S62-71. Epub 2007 Mar 30. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Manufactured for Douglas Laboratories 600 Boyce Road Pittsburgh, PA 15205 800-245-4440 © 2008 Douglas Laboratories. All Rights Reserved
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